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Loss of appetite While this supports weight loss, excessive loss of appetite may require dietary adjustments

In the study Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin , it was found that providing calcium supplementation to people taking metformin, was able to help prevent metformin-induced vitamin B12 deficiency

For standard oral B12 tablets or capsules, taking them with or without food generally makes little difference to absorption in individuals with normal gastrointestinal function

Also still feel fatigue

NNMT catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM, the universal methyl donor in cells) to nicotinamide (a form of vitamin B3 and a precursor for NAD+ synthesis), producing 1-methylnicotinamide and S-adenosylhomocysteine (SAH)